The severity of skin reactions to the treatment of actinic keratosis with 5-fluorouracil cream 4% was associated with a higher lesion clearance rate.

Fluorouracil interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA). Since DNA and RNA are essential for cell division ...

Once daily, 1 week AK lesion reduction from baseline: 28.8 Complete clearance: 0 AK lesion reduction from baseline: 62.6 Complete clearance: 18.1 <0.001 <0.001 In 5-FU group application, site ...

Immunotherapy. 2012;4(9):939-945. Potential reasons for the observed improvement in outcomes in vehicle groups include the natural regression of AK lesions, variation in investigator-determined ...