Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell through blood vessels and bodily fluids: special proteins that keep their ...

A new study highlighting the importance of a large protein complex called the exocyst in cell growth, division and ...

Eps15 immunoprecipitates with a number of endocytic proteins ... Eps15 was associated with vesicles in the presynaptic terminal but was virtually excluded from exocytic sites.

These extracellular vesicles (EVs), including exosomes and microvesicles, contain a multi-molecular cargo of proteins, nucleic acids, lipids and metabolites. Together with the number of EVs, this ...

“I work on a specific protein called SNAP-25,” says Bhasne. “Without SNAP-25, the SNARE complex, which is responsible for guiding the synaptic vesicle to the right docking points on the ...

Südhof and colleagues now show that SYT10 regulates a calcium-dependent exocytic pathway that ... express various established synaptic vesicle-related proteins. Moreover, depolarization of ...

“This study represents one of the first direct visualizations showing the localization of these two proteins on synaptic vesicle membranes,” she explains. Two other reports were published in t ...

Membrane protein trafficking in eukaryotes relies on dozens of protein complexes that recruit cargoes, drive vesicle budding, and catalyze vesicle fusion. While the biological roles of these membrane ...

Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain.