ACE inhibition is a sufficiently well accepted treatment modality, and most of the guidelines addressing treatment of hypertension, renal disease, and/or cardiovascular disease have this ...

These inhibitors are typically small molecules designed by considering the structure of the active site or the substrate specificity of the enzyme. A common problem with small inhibitors ...

11) and our understanding of ACE made a compelling argument for a new attempt at designing small molecular weight inhibitors. We had at our disposal not only an enzyme assay but also a highly ...

A study in mice offers evidence that inhibiting EZH2 can enhance lymphoma immunogenicity and overcome CAR-T cell therapy resistance.

An emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some cancer immunotherapies, ...

Inhibitors can be used to stop an enzyme from binding to its substrate. As a result, inhibitors can directly control the progress of a metabolic pathway.

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic-;an effective antiviral that has since successfully treated millions.

Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous substrate arachidonic acid, the mechanism of ...

This illustration depicts the process of enzyme catalysis. The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate ...