p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

The two proteins found to be mutated in this syndrome, ERCC8 and ERCC6, have been shown to be required for transcription-coupled repair. Of all the diseases listed in Table 1, Alzheimer's disease ...

Abbreviations: DDB1, xeroderma pigmentosum E; ERCC1, DNA excision repair protein ERCC-1; ERCC2–5, excision repair complementing factors (formerly known as XPD/XPB/XPF/XPG); ERCC6/8, Cockayne's ...