During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed ...

James Desmet explores Targeted Protein Degradation, a potential drug discovery strategy capable of treating previously ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other ...

Where most of the industry have programs targeting cereblon, a single E3 ligase that so far has only been demonstrated safe and efficacious in the cancer space, Captor has the tools to explore a ...

In this study, we will establish the role of RING genes in fungal susceptibility using a RING gene knockout collection and Botrytis cinerea as model pathogen, through the high-throughput screening ...

Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform, to identify and advance novel drug ...

We have taken a genomic approach to identify flower related Ubiquitin Proteasome System components from the RING type ubiquitin E3 ligase protein family. The Arabidopsis RING E3 ligases were retrieved ...