It is caused by haploinsufficiency of the Lis1 gene product, which seems to be required for proper functioning of cytoplasmic dynein during neuronal proliferation, migration and morphogenesis.

How proteins are specifically directed to these machineries and how the outcome of their ... D. (2009) Regulators of the cytoplasmic dynein motor. Nat Rev Mol Cell Biol. 10(12):854-65 Kardon, J. R., ...

Günter Blobel, known for his work on the signal hypothesis of protein targeting, has died from cancer at age 81. By varying the size of their steps, dynein motor proteins work effectively as teams to ...

In "The Handbook of Dynein,” 2nd edition. Pan Stanford Publishing. Editor Keiko Hirose. Zanacchi FC, Manzo C, Alvarez AS, Derr ND, Parajo MG, Lakadamyali M. (2017) A DNA origami platform for ...