Using silencer-seq, the Stark lab identified 800+ silencers and the transcription factor Saft in fruit flies, enhancing our ...

More recently, we have developed and validated a strategy that leverages Drosophila genetics to enhance the power of human genetic studies (Shulman et al. 2011). Despite the promise of genome-wide ...

In Drosophila melanogaster, RBF and dE2F proteins are key regulators of cell proliferation. E2F-protein control results from the functional interplay between activator and repressor complexes.

One defining characteristic of heterochromatin is its high levels of repeated DNA sequences, which make genome sequencing and molecular analysis very challenging. In Drosophila, a large proportion of ...

14 as "HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos." The zygotic genome remains transcriptionally silent in the early stage ...