Causes of portal hypertension can be prehepatic (such as portal vein thrombosis), hepatic (commonly liver cirrhosis and hepatic fibrosis) or posthepatic (such as hepatic vein obstruction).

Methods: Seventy patients with liver cirrhosis and portal hypertension were prospectively studied. Indication for laparoscopic splenectomy was bleeding tendency in 10 patients, induction of ...

which shows that the drug decreases portal hypertension and improves liver perfusion in patients with cirrhosis. Complications of portal hypertension include the development of esophageal varices ...