Hopes for this approach have now received a boost from a study by Van Kampen and Eckman, showing that activation of a particular dopamine receptor subtype stimulates neurogenesis and functional ...

The drug is a partial agonist that selectively targets dopamine D1/D5 receptor subtypes. Also in phase 2, the company has CVL-871 for dementia-related apathy and also has Fast Track status.

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

Serotonin (5-hydroxytryptamine [5-HT]) receptor subtypes, such as the 5-HT 1A receptor, are considered to mediate the ability of antipsychotic drugs to enhance cognition. On the other hand ...

Bioorg Med Chem Lett 18:3971-3973. [PubMed] Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL (2008). Synthesis and dopamine receptor affinities ofN-alkyl-11-hydroxy-2-methoxynoraporphines: N ...