Furthermore, new exons can be inserted into old introns, creating new proteins without disrupting the function of the old gene. Our knowledge of RNA splicing is quite new. Nonetheless, because ...

The scientific feat, which took more than a decade to complete, is published today in the journal Science. The spliceosome edits genetic messages transcribed from DNA, allowing cells to create ...

For instance, they can compare characteristic sequences of the gene and corresponding pre-mRNA, as well as splicing factors, across multiple experiments. These metacomparisons will integrate large ...

The scientific feat, which took more than a decade to complete, is published in the journal Science. The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

One such nuclear body, the speckle, contains spliceosomes that are known to be involved in mRNA splicing. Disruption of speckles leads to a range of diseases ... Guttman and his team are interested in ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain ...