Nature1 个月
A two-pronged approach to myotonic dystrophy type 1
An alteration in the causative gene, dystrophia myotonica protein kinase (DMPK), leads to a toxic messenger RNA (mRNA) that participates in the sequestration of muscleblind-like (MBNL) proteins ...
生物通2 年
约“惠”Capturem™膜技术，药物分析DMPK研究流程新突破！
不仅可以节省时间，还可以通过减少胰蛋白酶自溶来改善蛋白质组学分析中肽和蛋白质的鉴定。 药物分析DMPK研究样本量庞大，选择准确性高、重复性好的方法对于获得真实可靠的实验数据至关重要。以Capturem™ Trypsin 96-Well Plate为例，对3个不同孔进行稳定性和 ...
Investor's Business Daily on MSN1 个月
Avidity Biosciences, Up 441%, Nears Another Record High As Dystrophy Space Heats Up
The DMPK protein plays a key role in muscle, heart and brain cells. The company is currently running del-desiran in a Phase 3 ...
FierceBiotech6 天
Sarepta pays $500M cash for rights to 'multiple potential blockbusters' from Arrowhead
Sarepta Therapeutics is paying Arrowhead Pharmaceuticals $500 million in cash, plus a $325 million equity investment, for ...
Baylor College of Medicine4 年
Sara Johnson
Myotonic Dystrophy Type 1 (DM1) arises from an expanded microsatellite CTG repeat, (CTG)exp, in the Dystrophia Myotonica Protein Kinase (DMPK) gene. There are currently no treatments to slow disease ...
Unexpected findings provide a deeper understanding of myotonic dystrophy type 1
Carrying this mutated DMPK gene has a domino effect that alters ... The fetal heart predominantly expresses a fetal form of ...
News Medical1 个月
New insights into cardiac defects in Myotonic Dystrophy Type 1
Carrying this mutated DMPK gene has a domino effect that alters ... The fetal heart predominantly expresses a fetal form of protein SCN5A. As the individual develops, the heart produces less ...