For the cytotoxicity model, which was constructed using a large number of records, multitask learning did not affect precision but did reduce computation time. The models developed here were used ...

It is unclear if and when monoclonal antibodies (mAbs) that stimulate antibody-mediated cellular cytotoxicity (ADCC) can be used for treatment because this depends on the presence of functional ...

US FDA grants breakthrough therapy designation to Innate Pharma’s lacutamab for relapsed or refractory Sézary syndrome: Marseille, France Tuesday, February 18, 2025, 12:00 Hrs ...

Some reports suggest that the cytotoxicity of soluble CD95L is insignificant, whereas others show potent responses in vivo, including hepatocyte apoptosis that causes liver failure. We show here ...

尽管抗逆转录病毒治疗（ART）能够有效降低病毒载量，但HIV的潜伏库仍然存在，使得HIV感染无法完全治愈。HIV潜伏库主要存在于潜伏感染的CD4+ T细胞中，这些细胞在ART治疗下仍然可以被再激活并产生传染性病毒。因此，探索新的策略以清除HIV潜伏库是实现HIV治愈的关键。

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

In a recent study published in Science Translational Medicine, scientists used functional genomics to dissect and understand the cytotoxicity of spitting cobra venom and define the genetic ...