Disruptions in the dynamic balance of D1-receptor mediated phosphorylation and dephosphorylation cascades in different regions of the neuron may lead to impaired integration of synaptic inputs.

CDK2–cyclin A, CDK2–cyclin E, CDK4–cyclin D1, CDK5–p35, His-tagged Erk1 and Erk2, protein kinase C isoforms, the catalytic subunit of cAPK, cGMP-dependent protein kinase, casein kinases 1 ...

Kornfeld; Fredric E. Wondisford; Mehboob A. Hussain siRNA transfection achieved ∼40% knockdown of cyclin A2 protein(Fig. 5). This resulted in a significantly reduced Min6 proliferation rate (1. ...

Until now there hasn’t been a selective therapeutic agent to exploit this observation and so I am extremely excited to see Circle Pharma’s cyclin A/B RxL inhibitor move into the clinic." ...

WILKES-BARRE — Mayor George C. Brown's administration and city council are getting tougher on residents who are ruining the quality of life in the city. Failure to have a valid permit issued by ...

The naming of Wilkes-Barre began with a King's error. In 1662 King Charles II of England gave a charter to the Connecticut colony to certain lands in North America ...

During the meeting, Yunus sought the WB's support for the wide range of reforms the interim government had undertaken and asked the global lender to be creative about its lending programme ...

The city of Wilkes-Barre announced dates for a free, drive-through, electronics recycling and document shredding event for residents this October. The event will be held on Monday, October 7th ...

Planning a move to another town, city or state? The biggest factors in any move are the standard of living and what salary you’ll need to make in order to reach that standard. Our cost of living ...

WILKES-BARRE, LUZERNE COUNTY (WBRE/WYOU) — Following the much-anticipated debate between Vice President Kamala Harris and ...

For the 12th straight year, the Bruins have granted "Behind The B" cameras unprecedented access into the team's locker room, executive boardroom, and players' homes that will give fans a behind ...

Weibo (NASDAQ:WB) is a China-based social media platform that allows people to create, share, and discover content online. Weibo Corporation (NASDAQ:WB) operates in two segments: Advertising and ...