However, experiments in the mouse have shown added complexities, indicating that in the setting of a compromised p53 pathway, telomere-based crisis can facilitate carcinogenesis by promoting ...

The evidence supporting the relevance of replicative senescence of human cells and telomere biology to human cancer is now quite strong. The evidence linking replicative senescence to human aging ...

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...

“The novelty and merit of this work is that the authors demonstrate, for the first time, that [telomere transcription] occurs in response to physical exercise in a physiological system—human muscle,” ...

Researchers at Washington State University (WSU) have developed genetically engineered mice with human-like telomeres, offering a new model for studying aging and disease. The findings, published in ...

“This is the first mouse model with truly humanized telomeres because telomerase isn’t expressed in adult tissues in this model,” said Jiyue Zhu, PhD, professor, college of pharmacy and phar ...