However, experiments in the mouse have shown added complexities, indicating that in the setting of a compromised p53 pathway, telomere-based crisis can facilitate carcinogenesis by promoting ...

In the 1930s, Muller was surprised to note that telomeres were strangely resistant to mutagenic X-rays. Why are the unique properties of these chromosomal "end caps" so important? Thus ...

“The novelty and merit of this work is that the authors demonstrate, for the first time, that [telomere transcription] occurs in response to physical exercise in a physiological system—human muscle,” ...

People with shorter telomeres, the protective caps at the end of chromosomes, inside their white blood cells may be more likely to have strokes or develop dementia and late-life depression, ...

Researchers at Washington State University (WSU) have developed genetically engineered mice with human-like telomeres, offering a new model for studying aging and disease. The findings, published in ...

“This is the first mouse model with truly humanized telomeres because telomerase isn’t expressed in adult tissues in this model,” said Jiyue Zhu, PhD, professor, college of pharmacy and phar ...

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...