The gene cassette encoding Cre recombinase is usually engineered in a separate mouse strain. When Cre recombinase (red circle) is introduced, either as a transgene by crossing into a mouse line ...

The Irf8 floxed mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the identification of IRF8 ...