The resulting experimental mouse is hemizygous for Cre and homozygous for loxP (D). This is the necessary genotype required to conditionally knock out the target gene in the specific tissue. Laura is ...
The most straightforward way to examine the pattern of Cre-mediated recombination in the various tissues of the mouse is Southern blot analysis distinguishing wild-type, loxP-flanked and ...
the enzyme recognized the loxP sites and excised the STOP codon. Thus, active GFP expression served as an indicator of successful Cre delivery into the cells. But the true challenge lay ahead: to use ...
Related Links: Jackson Laboratory / Mutant Mouse Regional Resource Center (MMRRC ... On binding tamoxifen, the complex is translocated to the nucleus where cre activates recombination of loxP-flanked ...
The Yong Xu lab is interested in novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of metabolism and behavior. We generate unique mouse ...
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