A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can ...

The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Trends in Genetics 22, 46–55 (2006). Argueso, J. L. et al. Double-strand breaks associated with repetitive DNA can reshape the genome. Proceedings of the Naitonal Academy of Sciences 105 ...

We've now zoomed in enough to see portions of the DNA strand. The DNA is wrapped around histones -- protein structures that are sometimes depicted as discs. Histones carry a slight positive charge ...

In these sequences, the letters of the genetic code, the four base molecules adenine, cytosine, thymine and guanine, are ordered such that they have the same order as the second complementary ...

RNA polymerase moves along the DNA strand. Free RNA nucleotides form hydrogen bonds with the exposed DNA strand nucleotides by complementary base pairing to form a strand of mRNA: Note - RNA ...

When a complementary DNA strand is added, a stiffer double-stranded DNA molecule forms, pushing the pore open and allowing larger biomolecules to pass through. To close the pore, single-stranded ...

DNA polymerase enzymes use the existing DNA strand as a template and add the complementary nucleotides, including thymine, to the growing new strand. Mutations involving thymine can occur during DNA ...

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How Do At-Home DNA Kits Work? Most at-home DNA testing kits use saliva and provide a collection kit. Once you send your collection kit back to the company, they will likely either send it to a ...

the helix structure is unwound special molecules break the weak hydrogen bonds between bases, which are holding the two strands together this process occurs at several locations on a DNA molecule ...

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