Abnormalities in complement regulation lead directly to a variety of immunological diseases and are involved also in cardiovascular, immunological and rheumatic diseases.

“Under normal circumstances, a panel of complement regulators protects healthy cells from an attack by complement,” explains John Lambris, the Ralph and Sallie Weaver Professor of Research ...

Alternative pathway dysregulation is a central event in development of certain diseases caused by mutations or polymorphisms in complement regulator factor H (FH). While mutations in the C-terminal ...