“Under normal circumstances, a panel of complement regulators protects healthy cells from an attack by complement,” explains John Lambris, the Ralph and Sallie Weaver Professor of Research ...

how the system is controlled and how pathogenic microbes, parasites and tumor cells escape complement attack. Abnormalities in complement regulation lead directly to a variety of immunological ...

Alternative pathway dysregulation is a central event in development of certain diseases caused by mutations or polymorphisms in complement regulator factor H (FH). While mutations in the C-terminal ...