The epithelial cells that line our surfaces exist as single or multiple layers with flat, columnar or cuboidal appearance, depending on the tissue. Many epithelia are often exposed to physical ...

Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium.

Histologic diagnosis is based on finding intestinal metaplasia, including goblet cells, in columnar epithelium. Changes can be subtle, or obscured by inflammatory events. In this setting ...