In enzymes, this can be achieved either by ... can effectively catalyze the reaction. Figure 1: Reaction of the cofactor-independent dioxygenase DpgC. The pioneering work by Widboom et al.
These cofactors, or coenzymes, provide additional functionality that extends considerably the scope of enzyme-catalyzed reactions. Some cofactors (including the iron-porphyrin prosthetic groups of ...
They are involved, for example, in catalyzing chemical reactions ... to gain new insights into how the cofactor precursor is integrated into the enzyme and how individual amino acids are involved ...
Enzyme-bound flavin cofactors have spectroscopic signals that directly report on the chemistry occurring in the active site, which we exploit in order to study their reaction mechanisms using ...