These animals develop cirrhosis, portal hypertension, and HPS at 4–5 ... NO plays a central role in the pathophysiology of systemic and splanchnic vasodilation in cirrhosis.

Thus, HPS represents a relatively common and important cause of pulmonary disease in patients with cirrhosis. This review will focus on recent advances in our understanding of the pathophysiology ...

Causes of portal hypertension can be prehepatic (such as portal vein thrombosis), hepatic (commonly liver cirrhosis and hepatic fibrosis) or posthepatic (such as hepatic vein obstruction).

Treatment for portal hypertension in patients with cirrhosis is based on the use of β-blockers with or without organic nitrates; however, these agents are effective in less than 50% of patients ...