科学家们已经确定，CDCA7基因对于识别和促进部分甲基化DNA区域的修复是必要的。细胞分裂周期相关7 (CDCA7)基因的突变与不当的DNA甲基化有关，导致免疫缺陷、着丝粒不稳定和面部异常(ICF)综合征等疾病。研究人员发现，CDCA7在识别DNA的半甲基化区域和招募解旋酶 ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

CDCA7 binds to the hemimethylation site in the major groove of nucleosomal DNA without base-flipping. R274 confers preferential binding of CDCA7 to a hemimethylated CpG. The side chain of Q275 is ...

While it has been known that mutations in the CDCA7 gene cause ICF syndrome, little was known about the gene's molecular function. Now Rockefeller University's Funabiki lab, in close collaboration ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...