Its primary component, the Cas9 enzyme (orange), cuts genomic DNA (blue). The enzyme is directed to its target--essentially any sequence along the genome--by hitching it to a strand of guide RNA ...

Today’s mass-produced tomatoes often grow to palm-sized proportions, but their naturally occurring ancestors were far smaller ...

A CRISPR-Cas9-based investigational therapy was linked with a drop in serum transthyretin (TTR) levels in patients with ...

Crispr has already secured a historic first approval for a CRISPR/Cas9 drug and has several more potential blockbuster ...

Memorial Sloan Kettering Cancer Center-led researchers have identified a small molecule called gliocidin that kills ...

For this reason, compared with all previously available methods, it is much easier to ‘program’ CRISPR-Cas9 at a particular cutting point on the DNA strand. Various types of endonucleases – enzymes ...

Doudna said she does not support using CRISPR/Cas9 to make gene-edited babies. Base editors fuse enzymes that can alter the chemical structure of DNA bases to a “dead” version of CRISPR/Cas9 ...

“Our results demonstrate how the improved capabilities of engineered CRISPR-Cas9 enzymes can be beneficial, and together motivate additional studies using base editors to correct other mutations ...

There are six types of CRISPR ("clustered regularly interspaced short palindromic repeats") systems; CRISPR-Cas9, for example ...

Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly ... and two had transient liver-enzyme elevations that were assessed as treatment-related.

Cas9 has the potential to perform unintended ... an intermediate "surveillance" structure serves as a gatekeeper to regulate the enzyme's DNA cutting activity. This step is key to discriminating ...

Dr. Wilson is a biophysical scientist developing methods to deliver genome-editing enzymes such as CRISPR-Cas9. Dr. Wilson is a principal investigator at the University of California, Berkeley, ...