For this reason, compared with all previously available methods, it is much easier to ‘program’ CRISPR-Cas9 at a particular cutting point on the DNA strand. Various types of endonucleases – enzymes ...

What is CRISPR screening? The CRISPR-Cas9 technology uses the Cas9 enzyme and guide RNA to edit the genome at a particular point. There are three different mechanisms we use: the most common is ...

Its primary component, the Cas9 enzyme (orange), cuts genomic DNA (blue). The enzyme is directed to its target--essentially any sequence along the genome--by hitching it to a strand of guide RNA ...

Rotten tomatoes no more: growing sweeter tomatoes is possible by editing just two of the fruit’s genes. Deleting the genes ...

CRISPR-Cas9 is a powerful gene-editing tool that allows scientists to modify DNA in living organisms precisely. It works like ...

However, instead of using the Cas9 enzyme that is often used to edit DNA molecules, the investigators relied on a different ...

Crispr has already secured a historic first approval for a CRISPR/Cas9 drug and has several more potential blockbuster ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain ...

A breakthrough tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to create precise genetic mutations ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...