Since the first report of an improvement in migraine after intracardiac shunt closure in 2000, [5] more than a dozen additional reports have been published, all in support of a PFO–migraine ...

Several nonrandomized studies demonstrated a marked reduction of migraine (with and without aura) after percutaneous PFO closure; this benefit was observed in divers, patients with previous ...

A patent foramen ovale or PFO is a defect in the wall between the two upper chambers of the heart. This defect is actually an incomplete closure of the atrial wall that results in a flap ... can ...