Given that most pressor agents (sympathetic agonists, endothelin, or angiotensin-II) also stimulate contractility by directly activating their respective cardiac receptors and augment preload (by ...

The latter promotes phenotypic changes in these cells that are consistent with cardiac remodeling. The effects of ET are mediated through interaction with two classes of cell surface receptors.

Role of the RAAS in the Pathophysiology of Heart Failure ACE inhibitors have ... since they block the pathway more distally at the level of the receptor, whether the angiotensin II is formed ...