Cyclin-dependent kinases 12 and 13 (CDK12 and CDK13) are involved in the regulation of transcription elongation, DNA damage response and genomic stability balance. A few inhibitors of CDK12- and CDK13 ...

Cyclin-dependent kinases (CDKs ... includes 11 classical CDKs (CDK1–11), two newly proposed family members (CDK12 and 13) and additional proteins whose names are based on the presence of ...

在人工智能平台PandaOmics支持的适应症探索中，CDK12在多种肿瘤的潜在靶点列表中均排名前列。 ISM9274是一款靶向CDK12/13的高选择 ...

In a recent study published in Cell Reports Medicine, researchers investigated whether loss of the cyclin-dependent kinase 12 (CDK12) gene drives prostate cancer (PCa) development. Cyclin ...

Image Credit: Kateryna Kon/Shutterstock.com In a recent study published in Cell Reports Medicine, researchers investigated whether loss of the cyclin-dependent kinase 12 (CDK12) gene drives ...

In two new papers, both published in Cell Reports Medicine, they do both, describing the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and reporting on a promising ...

CDK12 is critical for proper chromosome alignment and progression through mitosis. Right: Without CDK12 the chromosomes become misaligned and detach from the spindle poles. Disclaimer: AAAS and ...

In two new papers, both published in Cell Reports Medicine, they do both, describing the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and reporting on a ...

Researchers previously found loss of the CDK12 gene in about 7% of patients with metastatic prostate cancer, suggesting this ...

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