Nature9 年
Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen ...
Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...
News Medical1 个月
Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation
Comparatively, GZMB-expressing KIR+ CD8+ T-cells have been found to suppress autoimmunity by eliminating autoreactive CD4+ T-cells. The current study is the first to report the persistence and re ...