As an orally available inhibitor of endothelin-1, which has been implicated in the pathogenesis of vascular disease in systemic sclerosis (SSc), bosentan is widely used as first-line therapy for ...

Bosentan is a dual endothelin-1-receptor antagonist that effectively treats idiopathic PAH and PAH related to connective tissue disease. Following preliminary trials of bosentan for the treatment ...

Bosentan 32mg; dispersible tabs for oral susp; tutti frutti flavor; contains phenylalanine. Must register patient in the Tracleer REMS Program (see full labeling). Take in the AM and PM. ≤12yrs ...

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