The blood-brain barrier ... inject drugs directly in the brain parenchyma or intrathecally through the outer covering of the brain (dura mater) into spaces where CSF circulates.

If targeted delivery to brain parenchyma is not the goal, alternative methods for crossing the blood–cerebrospinal fluid barrier may be considered or drugs may be introduced directly in the ...

The albumin ratio—the ratio of albumin protein in the cerebrospinal fluid compared to levels in the plasma or serum—is considered a measure of blood-brain barrier function, with higher values ...

CSF is important because whatever is in the fluid can cross over to affect brain function and activity. There are a few possible ways that the blood-brain barrier can be weakened, including ...

We are interested in the role of cerebrovascular injury and better understanding the pathophysiological processes that underpin pathological angiogenesis, blood-brain barrier (BBB) leakiness, and ...

and successfully crossed the blood-brain barrier, achieving significant and prolonged exposure in the cerebrospinal fluid (CSF). A-005 is a selective TYK2 inhibitor designed to treat ...

In a recent study, researchers from Uppsala University show that the Semliki Forest virus enters the central nervous system by first entering the cerebrospinal fluid and then binding to a specific ...