To induce heart failure, mice were subjected to pressure overload after 18 weeks of HFD. Long-term effects of ... intraperitoneally). Blood glucose levels from the tail vein were monitored over ...

treatment can selectively attenuate NASH caused by HFD mice. The results of these studies, while mixed in terms of efficacy, strongly suggest that the fermental supernatant treatment offers a safe ...

Design Faecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice were transplanted to the mice maintained on ND. The gut microbes, sperm count and motility were analysed. Human faecal ...

In this study, we identify an E3 ubiquitin ligase, tripartite motif-containing protein 32 (TRIM32), as a key regulator of hepatic insulin signaling that targets the insulin receptor (INSR) for ...

In NCD and HFD mice, TET2 KO mice showed improved glucose tolerance due to age-related increased insulin secretion. (a) IPGTT was performed in TET2 WT and KO mice fed NCD at weeks 8, 16, 32, and 52 to ...

The mice were kept in the animal facility of Shanghai Jiao Tong University with a controlled temperature (20 ± 2°C), humidity (60 ± 5%) and a 12 h dark/light cycle. The control mice were fed a regular ...