Unlock Mom's Knife by beating Satan with Isaac for a game-changing, penetrating knife. In The Binding of Isaac: Rebirth, players take Isaac on a dangerous journey through his mom's basement.

Obtain Holy Mantle for one-time protection from first damage in each room, essential for survival. Acquire items like Death's Touch to pierce enemies and Abaddon for stat boosts and special tears.

The Binding of Isaac: Rebirth's long-awaited free online co-op mode finally has a release date. Creator Edmund McMillen ...