In both human muscle cells and mouse brown adipocytes, bile acids increased D2 activity and oxygen consumption by binding to the G-protein-coupled receptor TGR5, causing cyclic AMP levels to rise.

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles.

functions as a receptor for both vitamin D and secondary bile acids. The vitamin D receptor activates important detoxification genes that are targets of xenobiotic receptors. Xenobiotic receptors ...

Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases that spreads among individuals through blood ...

Hepatitis B virus (HBV) has a narrow host range, mainly infecting hominoids. A new study reveals the structural differences in the liver cell receptor (NTCP) between humans and monkeys, explaining why ...

In this study, the researchers experimentally verified that the pruritus caused by OCA is also mediated through the activation of the hX4 receptor. - Building on the bile acid activating hX4 ...

and his colleagues at first thought that DLPC would provide a useful tool in studying the function of a receptor protein – liver receptor homolog -1 or LRH-1 – that regulates the production of bile ...

A study reveals why monkeys resist HBV infection, showing that specific amino acid differences in their NTCP receptor prevent ...

Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases, that spreads among individuals through blood or body fluids. According ...