In both human muscle cells and mouse brown adipocytes, bile acids increased D2 activity and oxygen consumption by binding to the G-protein-coupled receptor TGR5, causing cyclic AMP levels to rise.

functions as a receptor for both vitamin D and secondary bile acids. The vitamin D receptor activates important detoxification genes that are targets of xenobiotic receptors. Xenobiotic receptors ...

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles.

In this study, the researchers experimentally verified that the pruritus caused by OCA is also mediated through the activation of the hX4 receptor. - Building on the bile acid activating hX4 ...

and his colleagues at first thought that DLPC would provide a useful tool in studying the function of a receptor protein – liver receptor homolog -1 or LRH-1 – that regulates the production of bile ...

Inulin, a type of fiber found naturally in foods like bananas, asparagus, and garlic, is often concentrated in dietary ...

Intercept’s US president Vivek Devaraj said the pharma company still believes in the evidence supporting the liver disease ...

Ipsen has shared positive three-year results for Iqirvo (elafibranor) in patients with the rare cholestatic liver disease ...