Hulk's need for oxygen is how Batman beat him during their epic Marvel/DC crossover fight. Thankfully, the series did offer fans a comforting epilogue, as Bruce Banner (and Tony Stark, who also ...

specifically in 1981s Batman vs. The Incredible Hulk #1, (also written by Len Wein), where The Dark Knight of DC Comics utilizes a similar oxygen-cutting strategy to beat Marvels Jade Giant.