研究人员发现，即使没有二次突变，单个错误的BRCA1拷贝也会使乳腺细胞更容易罹患癌症，并足以引发肿瘤生长。这项研究成果于2024年11月11日发表在《Nature Genetics》杂志上。 众所周知，我们从父母那里获得了每个基因的两个拷贝，这是进化过程中的一个防故障 ...

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

Having a mutated BRCA1 gene can mean a death sentence for those affected. Those with the faulty gene have up to an 87% lifetime risk of developing breast cancer and up to a 60% lifetime risk of ...

Female carriers of germline BRCA1 mutations have a lifetime risk of breast cancer exceeding 80% and of ovarian cancer approaching 60%. The cumulative lifetime risk of developing either breast or ...