CLOCK acetylates (Ac) histones H3 and H4 in nucleosomes (green) to confer 'open' chromatin structure and enable CLOCK-BMAL1 to bind to the E-boxes in cognate promoters and turn on transcription.
Removing the clock gene BMAL1 makes bacteria-engulfing defence cells in the body more effective, a University of Manchester and University of Oxford study published in the journal PNAS has found. This ...
Why do asthma, heart attacks and many other health conditions tend to strike in the early hours of the morning? One possible ...
Why do asthma, heart attacks and many other health conditions tend to strike in the early hours of the morning? One possible ...