In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

The US Food and Drug Administration (FDA) has granted approval for Astellas Pharma’s azole antifungal drug Cresemba (isavuconazonium sulfate) to treat children with invasive aspergillosis (IA ...

It described antifungal resistance to azoles, and then defined optimal methods for testing which is now a global issue, partly related to azole fungicide use on crops. International collaborations ...

Second, there is a greater chance of drug interactions. Azole antifungals (e.g., fluconazole, itraconazole and voriconazole) alter metabolism of cyclophosphamide, a cytotoxic agent, through ...