Autophagy has been recently shown to be an important component of the innate immune response by degrading foreign microbial invaders. The upstream signaling pathways leading to activation of autophagy ...

Autophagy is a natural regeneration process that occurs at a cellular level in the body, reducing the likelihood of contracting some diseases as well as prolonging lifespan. In 2016, Japanese ...

2). AMPK signaling is also well known to activate the nutrient recycling mechanism autophagy. We have therefore found that starvation signaling can induce two distinct cellular responses, to promote ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

Damaged or superfluous proteins and other components inside a cell are broken down in a process called autophagy. Aging research has established that autophagy pathways become less active with age ...

We have observed implantation defects and thus, reduced fecundity in conditional knockout mice models of the autophagy-related proteins in the reproductive tract. In the absence of these proteins, we ...