conclude that the suitability of atenolol as an antihypertensive agent is now uncertain. Its role as a reference drug in trials of antihypertensive agents might no longer be appropriate.

Atenolol and metoprolol have many things in common, including drug class, where they work in the body, and conditions they ...

The β-blocker atenolol is used widely as a first-line treatment for hypertension and as a reference drug in clinical trials. Prompted by a finding that the angiotensin-receptor blocker losartan ...