Enzymes are crucial to life. They are nature's little catalysts. In the gut, they help us digest food. They can enhance ...

One example is phenylketonuria (or PKU), a rare inherited disease where the body lacks the enzyme to process proteins. Because of this, toxic molecules can build up, and if they travel to the brain, ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases ...

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate ...

We have investigated the prediction of protein interactions through the analysis of domain fusion to assess whether metabolic enzymes have a higher participation in gene-fusion events compared ...

Researchers at Tufts University revealed a possible molecular mechanism explaining how the DNA repeats are broken and then expanded in the Huntington’s disease gene, pointing to a component of the ...

The work overcomes current conventional approaches to enzyme engineering, which are limited across multiple dimensions: Small functional datasets lead to missed interactions among different amino acid ...