One antisense drug, Isis Pharmaceuticals' (Carlsbad ... application of further chemical modifications such as peptide nucleic acids (PNAs), locked nucleic acid (LNA), and phosporodiamidate ...
Nucleic acid therapeutics use engineered sequences ... there’s no question that siRNAs are way superior to antisense,” says Anastasia Khvorova, an RNA therapeutics specialist at the University ...
A specialised treatment called a Gapmer antisense oligonucleotide (ASO ... Published in Molecular Therapeutics Nucleic Acids, a top journal in the field of nucleic-acid based therapeutics ...