In cultured prostate carcinoma cells, these compounds inhibited androgen receptor signalling more potently than competitive antagonists, in a manner consistent with their being non-competitive ...

Prostate cancer (PCa) is one of the most frequently diagnosed malignancies in men. Androgen-deprivation therapy (ADT) is the first-line treatment and fundamental management for men with advanced ...

The key to this resistance may lie in expression of the androgen receptor itself. Most patients with metastatic prostate cancer receive drugs that block production of androgen, which promotes ...

Androgen receptor (AR) signaling is the primary driver of prostate cancer (PCa) disease progression, resulting in about 27,500 deaths per year in the US. First line treatment of PCa is androgen ...

While most prostate cancers initially respond to androgen receptor-blocking therapies ... which no longer relies on androgen signaling and is therefore difficult to treat. Understanding this ...

This article explores how peptides and SARMs work, their unique benefits, and their combined potential to achieve fitness ...

While most prostate cancers initially respond to androgen receptor-blocking therapies ... which no longer relies on androgen signaling and is therefore difficult to treat. Understanding this ...

PSMA-PET imaging can detect radiorecurrent prostate cancer lesions in patients even when PSA levels are below current Phoenix criteria for biochemical recurrence, investigators reported at the 2024 ...