Local amyloid deposition occurs in the brain in Alzheimer's disease and in the pancreas in maturity-onset diabetes, but a direct role in the pathogenesis of these diseases remains unproven.

This review provides an overview of Alzheimer’s disease (AD), discussing its complex pathophysiology, risk factors, and ...

Multiple myeloma and AL amyloidosis are conditions linked to plasma cells in the bone marrow. Multiple myeloma (MM) is a cancer affecting the plasma cells, which are mostly in the bone marrow.

Hereditary transthyretin (hATTR) amyloidosis is a rare disease that runs in families. It is caused by the buildup of toxic ...

Notably, of the papers our experts chose as the most important, 95% are related to the processing or pathogenesis of amyloid-β, a peptide that clumps to form the extracellular plaques in the ...

The trial reports the first data of anti-BCMA CART treatment in AL amyloidosis. The high response rates and manageable toxicity profile are promising and provide the basis for future CART trials in AL ...