Local amyloid deposition occurs in the brain in Alzheimer's disease and in the pancreas in maturity-onset diabetes, but a direct role in the pathogenesis of these diseases remains unproven.

The amyloid cascade hypothesis of AD pathogenesis has historically been treated as a monolithic hypothesis, fostering the notion that approaches targeting Aβ monomers or amyloid plaques as a ...

director of the Amyloidosis Center at the Chobanian & Avedisian School of Medicine and Boston Medical Center, focused on recent advances in the understanding of pathogenesis, clinical syndromes ...

Multiple myeloma and AL amyloidosis are conditions linked to plasma cells in the bone marrow. Multiple myeloma (MM) is a cancer affecting the plasma cells, which are mostly in the bone marrow.

Hereditary transthyretin (hATTR) amyloidosis is a rare disease that runs in families. It is caused by the buildup of toxic ...

Responses were almost universal (15/16), with frequent complete responses (12/16), translating into organ responses. The trial reports the first data of anti-BCMA CART treatment in AL amyloidosis. The ...