Misfolded proteins not only lose their normal physiological functions, but can also acquire new properties that drive pathological processes leading to disease. Amyloid plaques comprising tangled ...

clinicians may not be thinking about rarer diseases such as hereditary ATTR amyloidosis. There’s an adage in medicine that says if you hear hoof-beats, think of horses not zebras. Hereditary ...

Cardiac amyloidosis can also affect the heart's electrical system, causing an irregular heart rhythm. There are some genetic factors that increase the risk of developing heart disease in certain ...

Diagnosis and treatment may be challenging at first because the symptoms and causes vary between different types of amyloidosis. They may also mimic other conditions, such as heart disease.

While AL amyloidosis is the most common type of amyloidosis, it remains a rare disease with an estimated 30,000 to 45,000 people living with the disease in the US and Europe.

Renal amyloidosis was diagnosed if biopsies of deposits were Congo red positive and/or demonstrated fibrillar morphology by ultrastructural analysis. Amyloid was then subclassified by ...

Of these, 5 had renal biopsy–confirmed renal AL amyloidosis, and 1 had LCDD. All 5 patients with AL amyloidosis had λ Bence Jones proteinuria. The only patient in our study with renal LCDD had ...