The symptoms of hyperkalemia begin with muscle weakness. As serum potassium levels rise, symptoms progress to more significant muscle twitching, weakness, nausea, and cramping. [69] Cardiac ...

Potassium and renal function must be routinely assessed to minimize the risk of life-threatening hyperkalemia. This review discusses the role of aldosterone antagonists in the treatment of heart ...

Aldosterone is a hormone produced in the adrenal gland. This steroid molecule, derived from cholesterol, promotes retention of sodium and water and lowers the levels of potassium in the blood ...

Compared with placebo, sodium zirconium cyclosilicate was associated with less need to lower or discontinue spironolactone.

Contraindicated in patients with high potassium levels in the blood, aluminum toxicity, heart failure or injury, or severe kidney problems, who are taking aldosterone blocker and hypersensitivity.

increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume ...