Aldosterone antagonists, such as spironolactone or potassium canrenoate, are the preferred first-line diuretics in the management of patients with cirrhosis and ascites, because aldosterone is the ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

with little focus on the role of aldosterone. From a therapeutic standpoint, the mineralocorticoid receptor antagonist spironolactone has been available for over 40 years, but its use has been ...